I want to dedicate this book to my Parents since they have always supported my career objectives and actively tried to give me the protected academic time I needed to achieve those goals. This book is focused on current machine learning research issues that are giving the industry a practical way to design Internet of Things (IoT) solutions quickly. Machine learning algorithms allow for the speedy creation and development of IoT solutions by the industry. The Open IoT cloud platform can be used to create large-scale applications. However, when using this design, there are concerns with energy efficiency, sensing data quality, network resource utilization, and latency. The focus of this special issue is on machine learning, data analytics, and optimization in IoT applications, with a focus on processing power constraints and optimization problems in industrial informatics.